Cargando…

Direct Stimulation of Islet Insulin Secretion by Glycolytic and Mitochondrial Metabolites in KCl-Depolarized Islets

We have previously demonstrated that islet depolarization with 70 mM KCl opens Cx36 hemichannels and allows diffusion of small metabolites and cofactors through the β-cell plasma membrane. We have investigated in this islet “permeabilized” model whether glycolytic and citric acid cycle intermediates...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pizarro-Delgado, Javier, Deeney, Jude T., Corkey, Barbara E., Tamarit-Rodriguez, Jorge
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112877/ https://www.ncbi.nlm.nih.gov/pubmed/27851770 http://dx.doi.org/10.1371/journal.pone.0166111

Ejemplares similares

KCl -Permeabilized Pancreatic Islets: An Experimental Model to Explore the Messenger Role of ATP in the Mechanism of Insulin Secretion
por: Pizarro-Delgado, Javier, et al.
Publicado: (2015)

Reactive Oxygen Species Stimulate Insulin Secretion in Rat Pancreatic Islets: Studies Using Mono-Oleoyl-Glycerol
por: Saadeh, Marylana, et al.
Publicado: (2012)

Inhibition of Monoacylglycerol Lipase Activity Decreases Glucose-Stimulated Insulin Secretion in INS-1 (832/13) Cells and Rat Islets
por: Berdan, Charles A., et al.
Publicado: (2016)

Follicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets
por: Cheng, Yi, et al.
Publicado: (2023)

Islet-enriched gene expression and glucose-induced insulin secretion in human and mouse islets
por: Dai, C., et al.
Publicado: (2011)

Islet primary cilia motility controls insulin secretion
por: Cho, Jung Hoon, et al.
Publicado: (2022)

Mitochondrial Carriers Regulating Insulin Secretion Profiled in Human Islets upon Metabolic Stress
por: Jimenez-Sánchez, Cecilia, et al.
Publicado: (2020)

Nutrient-stimulated insulin secretion in mouse islets is critically dependent on intracellular pH
por: Gunawardana, Subhadra C, et al.
Publicado: (2004)

OR09-5 Importance of Islet Intracrinology for Glucose-Stimulated Insulin Secretion (GSIS) in the Male
por: Xu, Weiwei, et al.
Publicado: (2019)

Lorcaserin Inhibit Glucose-Stimulated Insulin Secretion and Calcium Influx in Murine Pancreatic Islets
por: Jing, Muhan, et al.
Publicado: (2021)

Mechanistic Investigation of GHS-R Mediated Glucose-Stimulated Insulin Secretion in Pancreatic Islets
por: Pradhan, Geetali, et al.
Publicado: (2022)

Glucose-stimulated insulin secretion depends on FFA1 and Gq in neonatal mouse islets
por: Lorza-Gil, Estela, et al.
Publicado: (2023)

Steviol glucuronide, a metabolite of steviol glycosides, potently stimulates insulin secretion from isolated mouse islets: Studies in vitro
por: Gu, Wenqian, et al.
Publicado: (2019)

MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response
por: Lin, Danhong, et al.
Publicado: (2023)

A Microfluidic Hanging-Drop-Based Islet Perifusion System for Studying Glucose-Stimulated Insulin Secretion From Multiple Individual Pancreatic Islets
por: Wu Jin, Patricia, et al.
Publicado: (2021)

HDAC7 is overexpressed in human diabetic islets and impairs insulin secretion in rat islets and clonal beta cells
por: Daneshpajooh, Mahboubeh, et al.
Publicado: (2016)

Possible modulatory effect of endogenous islet catecholamines on insulin secretion
por: Borelli, Maria I, et al.
Publicado: (2001)

The effect of unhealthy β-cells on insulin secretion in pancreatic islets
por: Pu, Yang, et al.
Publicado: (2013)

Control of Insulin Secretion by Cholinergic Signaling in the Human Pancreatic Islet
por: Molina, Judith, et al.
Publicado: (2014)

ADCY5 Couples Glucose to Insulin Secretion in Human Islets
por: Hodson, David J., et al.
Publicado: (2014)

Respiratory Parameters for the Classification of Dysfunctional Insulin Secretion by Pancreatic Islets
por: Kabra, Uma D., et al.
Publicado: (2021)

TRPC3 Regulates Islet Beta‐Cell Insulin Secretion
por: Rached, Gaëlle, et al.
Publicado: (2023)

Nutrient regulation of the islet epigenome controls adaptive insulin secretion
por: Wortham, Matthew, et al.
Publicado: (2023)

Enterovirus infection of human islets of Langerhans affects β-cell function resulting in disintegrated islets, decreased glucose stimulated insulin secretion and loss of Golgi structure
por: Hodik, M, et al.
Publicado: (2016)

The Redox Communication Network as a Regulator of Metabolism
por: Corkey, Barbara E., et al.
Publicado: (2020)

Restructuring of Pancreatic Islets and Insulin Secretion in a Postnatal Critical Window
por: Aguayo-Mazzucato, Cristina, et al.
Publicado: (2006)

Differential Effects of Voclosporin and Tacrolimus on Insulin Secretion From Human Islets
por: Kolic, Jelena, et al.
Publicado: (2020)

Protocol for in vivo and ex vivo assessments of glucose-stimulated insulin secretion in mouse islet β cells
por: Zhu, Yun-Xia, et al.
Publicado: (2021)

Stimulation of neurite outgrowth in PC12 cells by EGF and KCl depolarization: a Ca(2+)-independent phenomenon
Publicado: (1995)

Insulin secretion from beta cells within intact islets: Location matters
por: Hoang Do, Oanh, et al.
Publicado: (2015)

Dynamics and Regulation of Insulin Secretion in Pancreatic Islets from Normal Young Children
por: Henquin, Jean-Claude, et al.
Publicado: (2016)

Simvastatin Rapidly and Reversibly Inhibits Insulin Secretion in Intact Single-Islet Cultures
por: Scattolini, Valentina, et al.
Publicado: (2016)

Immaturity of insulin secretion by pancreatic islets isolated from one human neonate
por: Henquin, Jean‐Claude, et al.
Publicado: (2017)

Glutamate decarboxylase 67 contributes to compensatory insulin secretion in aged pancreatic islets
por: Cho, Jung Hoon, et al.
Publicado: (2019)

Eugenol Improves Insulin Secretion and Content of Pancreatic Islets from Male Mouse
por: Oroojan, Ali Akbar
Publicado: (2020)

Islet Health, Hormone Secretion, and Insulin Responsivity with Low-Carbohydrate Feeding in Diabetes
por: Locatelli, Cassandra A. A., et al.
Publicado: (2020)

Heterogeneous expression of CFTR in insulin-secreting β-cells of the normal human islet
por: Di Fulvio, Mauricio, et al.
Publicado: (2020)

Improvement of Lipotoxicity-Induced Islet β Cellular Insulin Secretion Disorder by Osteocalcin
por: Zhang, Yafang, et al.
Publicado: (2022)

Homogeneous Insulin and C-Peptide Sensors for Rapid Assessment of Insulin and C-Peptide Secretion by the Islets
por: Heyduk, Ewa, et al.
Publicado: (2010)

Differences in insulin biosynthesis pathway between small and large islets do not correspond to insulin secretion
por: Huang, Han-Hung, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_tvhb4e17vlijgi7u0j022m81nn