Disruption of Higher Order DNA Structures in Friedreich’s Ataxia (GAA)(n) Repeats by PNA or LNA Targeting

Expansion of (GAA)(n) repeats in the first intron of the Frataxin gene is associated with reduced mRNA and protein levels and the development of Friedreich’s ataxia. (GAA)(n) expansions form non-canonical structures, including intramolecular triplex (H-DNA), and R-loops and are associated with epige...

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Detalles Bibliográficos
Autores principales: Bergquist, Helen, Rocha, Cristina S. J., Álvarez-Asencio, Rubén, Nguyen, Chi-Hung, Rutland, Mark. W., Smith, C. I. Edvard, Good, Liam, Nielsen, Peter E., Zain, Rula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112992/
https://www.ncbi.nlm.nih.gov/pubmed/27846236
http://dx.doi.org/10.1371/journal.pone.0165788

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112992/
https://www.ncbi.nlm.nih.gov/pubmed/27846236
http://dx.doi.org/10.1371/journal.pone.0165788

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