Disruption of Higher Order DNA Structures in Friedreich’s Ataxia (GAA)(n) Repeats by PNA or LNA Targeting
Expansion of (GAA)(n) repeats in the first intron of the Frataxin gene is associated with reduced mRNA and protein levels and the development of Friedreich’s ataxia. (GAA)(n) expansions form non-canonical structures, including intramolecular triplex (H-DNA), and R-loops and are associated with epige...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5112992/ https://www.ncbi.nlm.nih.gov/pubmed/27846236 http://dx.doi.org/10.1371/journal.pone.0165788 |