Antagonizing STAT5B dimerization with an osmium complex

Targeting STAT5 is an appealing therapeutic strategy for the treatment of hematologic malignancies and inflammation. Here, we present the novel osmium(II) complex 1 as the first metal-based inhibitor of STAT5B dimerization. Complex 1 exhibited superior inhibitory activity against STAT5B DNA binding...

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Detalles Bibliográficos
Autores principales: Liu, Li-Juan, Wang, Wanhe, Kang, Tian-Shu, Liang, Jia-Xin, Liu, Chenfu, Kwong, Daniel W. J., Wong, Vincent Kam Wai, Ma, Dik-Lung, Leung, Chung-Hang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113070/
https://www.ncbi.nlm.nih.gov/pubmed/27853239
http://dx.doi.org/10.1038/srep36044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113070/
https://www.ncbi.nlm.nih.gov/pubmed/27853239
http://dx.doi.org/10.1038/srep36044

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