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Anticodon-like binding of the HIV-1 tRNA-like element to human lysyl-tRNA synthetase

A critical step in the HIV-1 lifecycle involves reverse transcription of the viral genomic RNA (gRNA). Human tRNA(Lys3) serves as a primer for transcription initiation and is selectively enriched in virus particles. Human lysyl-tRNA synthetase (hLysRS) is also packaged into virions. Recently, a tRNA...

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Detalles Bibliográficos
Autores principales: Liu, Sheng, Comandur, Roopa, Jones, Christopher P., Tsang, Pearl, Musier-Forsyth, Karin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113203/
https://www.ncbi.nlm.nih.gov/pubmed/27852925
http://dx.doi.org/10.1261/rna.058081.116