Brincidofovir Is Not a Substrate for the Human Organic Anion Transporter 1: A Mechanistic Explanation for the Lack of Nephrotoxicity Observed in Clinical Studies

BACKGROUND: Brincidofovir (BCV) is an orally bioavailable lipid conjugate of cidofovir (CDV) with increased in vitro potency relative to CDV against all 5 families of double-stranded DNA viruses that cause human disease. After intravenous (IV) administration of CDV, the organic anion transporter 1 (...

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Detalles Bibliográficos
Autores principales: Tippin, Timothy K., Morrison, Marion E., Brundage, Thomas M., Momméja-Marin, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Therapeutic Drug Monitoring 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113238/
https://www.ncbi.nlm.nih.gov/pubmed/27851688
http://dx.doi.org/10.1097/FTD.0000000000000353

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113238/
https://www.ncbi.nlm.nih.gov/pubmed/27851688
http://dx.doi.org/10.1097/FTD.0000000000000353

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