Synthesis of Highly Selective Submicromolar Microcystin‐Based Inhibitors of Protein Phosphatase (PP)2A over PP1

Research and therapeutic targeting of the phosphoserine/threonine phosphatases PP1 and PP2A is hindered by the lack of selective inhibitors. The microcystin (MC) natural toxins target both phosphatases with equal potency, and their complex synthesis has complicated structure–activity relationship st...

Descripción completa

Detalles Bibliográficos
Autores principales: Fontanillo, Miriam, Zemskov, Ivan, Häfner, Maximilian, Uhrig, Ulrike, Salvi, Francesca, Simon, Bernd, Wittmann, Valentin, Köhn, Maja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113787/
https://www.ncbi.nlm.nih.gov/pubmed/27723199
http://dx.doi.org/10.1002/anie.201606449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113787/
https://www.ncbi.nlm.nih.gov/pubmed/27723199
http://dx.doi.org/10.1002/anie.201606449

Ejemplares similares