Evidence that Processing of the Severe Fever with Thrombocytopenia Syndrome Virus Gn/Gc Polyprotein Is Critical for Viral Infectivity and Requires an Internal Gc Signal Peptide

The severe fever with thrombocytopenia syndrome virus (SFTSV) is an emerging, highly pathogenic bunyavirus against which neither antivirals nor vaccines are available. The SFTSV glycoproteins, Gn and Gc, facilitate viral entry into host cells. Gn and Gc are generated from a precursor protein, Gn/Gc,...

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Detalles Bibliográficos
Autores principales: Plegge, Teresa, Hofmann-Winkler, Heike, Spiegel, Martin, Pöhlmann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113920/
https://www.ncbi.nlm.nih.gov/pubmed/27855227
http://dx.doi.org/10.1371/journal.pone.0166013

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113920/
https://www.ncbi.nlm.nih.gov/pubmed/27855227
http://dx.doi.org/10.1371/journal.pone.0166013

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