The novel mitochondria-targeted hydrogen sulfide (H(2)S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro

The development of diabetic vascular complications is initiated, at least in part, by mitochondrial reactive oxygen species (ROS) production in endothelial cells. Hyperglycemia induces superoxide production in the mitochondria and initiates changes in the mitochondrial membrane potential that leads...

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Detalles Bibliográficos
Autores principales: Gerő, Domokos, Torregrossa, Roberta, Perry, Alexis, Waters, Alicia, Le-Trionnaire, Sophie, Whatmore, Jacqueline L., Wood, Mark, Whiteman, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2016
Materias:
Invited Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113977/
https://www.ncbi.nlm.nih.gov/pubmed/27565382
http://dx.doi.org/10.1016/j.phrs.2016.08.019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113977/
https://www.ncbi.nlm.nih.gov/pubmed/27565382
http://dx.doi.org/10.1016/j.phrs.2016.08.019

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