Potent and Broad Inhibition of HIV-1 by a Peptide from the gp41 Heptad Repeat-2 Domain Conjugated to the CXCR4 Amino Terminus

HIV-1 entry can be inhibited by soluble peptides from the gp41 heptad repeat-2 (HR2) domain that interfere with formation of the 6-helix bundle during fusion. Inhibition has also been seen when these peptides are conjugated to anchoring molecules and over-expressed on the cell surface. We hypothesiz...

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Detalles Bibliográficos
Autores principales: Leslie, George J., Wang, Jianbin, Richardson, Max W., Haggarty, Beth S., Hua, Kevin L., Duong, Jennifer, Secreto, Anthony J., Jordon, Andrea P. O., Romano, Josephine, Kumar, Kritika E., DeClercq, Joshua J., Gregory, Philip D., June, Carl H., Root, Michael J., Riley, James L., Holmes, Michael C., Hoxie, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113989/
https://www.ncbi.nlm.nih.gov/pubmed/27855210
http://dx.doi.org/10.1371/journal.ppat.1005983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5113989/
https://www.ncbi.nlm.nih.gov/pubmed/27855210
http://dx.doi.org/10.1371/journal.ppat.1005983

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