Cargando…

The fail-safe mechanism of post-transcriptional silencing of unspliced HAC1 mRNA

HAC1 encodes a transcription factor that is the central effector of the unfolded protein response (UPR) in budding yeast. When the UPR is inactive, HAC1 mRNA is stored as an unspliced isoform in the cytoplasm and no Hac1 protein is detectable. Intron removal is both necessary and sufficient to relie...

Descripción completa

Detalles Bibliográficos
Autores principales: Di Santo, Rachael, Aboulhouda, Soufiane, Weinberg, David E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114014/
https://www.ncbi.nlm.nih.gov/pubmed/27692069
http://dx.doi.org/10.7554/eLife.20069