Haploinsufficiency of the 22q11.2 microdeletion gene Mrpl40 disrupts short-term synaptic plasticity and working memory through dysregulation of mitochondrial calcium

Hemizygous deletion of a 1.5- to 3-megabase region on chromosome 22 causes 22q11.2 deletion syndrome (22q11DS), which constitutes one of the strongest genetic risks for schizophrenia. Mouse models of 22q11DS have abnormal short-term synaptic plasticity that contributes to working-memory deficiencies...

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Detalles Bibliográficos
Autores principales: Devaraju, P, Yu, J, Eddins, D, Mellado-Lagarde, M M, Earls, L R, Westmoreland, J J, Quarato, G, Green, D R, Zakharenko, S S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114177/
https://www.ncbi.nlm.nih.gov/pubmed/27184122
http://dx.doi.org/10.1038/mp.2016.75

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114177/
https://www.ncbi.nlm.nih.gov/pubmed/27184122
http://dx.doi.org/10.1038/mp.2016.75

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