Different DNA End Configurations Dictate Which NHEJ Components Are Most Important for Joining Efficiency

The nonhomologous DNA end-joining (NHEJ) pathway is a key mechanism for repairing dsDNA breaks that occur often in eukaryotic cells. In the simplest model, these breaks are first recognized by Ku, which then interacts with other NHEJ proteins to improve their affinity at DNA ends. These include DNA-...

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Detalles Bibliográficos
Autores principales: Chang, Howard H. Y., Watanabe, Go, Gerodimos, Christina A., Ochi, Takashi, Blundell, Tom L., Jackson, Stephen P., Lieber, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2016
Materias:
DNA and Chromosomes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114395/
https://www.ncbi.nlm.nih.gov/pubmed/27703001
http://dx.doi.org/10.1074/jbc.M116.752329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114395/
https://www.ncbi.nlm.nih.gov/pubmed/27703001
http://dx.doi.org/10.1074/jbc.M116.752329

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