Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

Mitochondrial DNA (mtDNA) often exists in a state of heteroplasmy, in which mutant mtDNA co-exists in cells with wild-type mtDNA. High frequencies of pathogenic mtDNA result in maternally inherited diseases; maternally and somatically acquired mutations also accumulate over time and contribute to di...

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Detalles Bibliográficos
Autores principales: Kandul, Nikolay P., Zhang, Ting, Hay, Bruce A., Guo, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114534/
https://www.ncbi.nlm.nih.gov/pubmed/27841259
http://dx.doi.org/10.1038/ncomms13100

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114534/
https://www.ncbi.nlm.nih.gov/pubmed/27841259
http://dx.doi.org/10.1038/ncomms13100

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