Cargando…

Selective removal of deletion-bearing mitochondrial DNA in heteroplasmic Drosophila

Mitochondrial DNA (mtDNA) often exists in a state of heteroplasmy, in which mutant mtDNA co-exists in cells with wild-type mtDNA. High frequencies of pathogenic mtDNA result in maternally inherited diseases; maternally and somatically acquired mutations also accumulate over time and contribute to di...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kandul, Nikolay P., Zhang, Ting, Hay, Bruce A., Guo, Ming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2016
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114534/ https://www.ncbi.nlm.nih.gov/pubmed/27841259 http://dx.doi.org/10.1038/ncomms13100

Ejemplares similares

Mutant C. elegans mitofusin leads to selective removal of mtDNA heteroplasmic deletions across generations to maintain fitness
por: Meshnik, Lana, et al.
Publicado: (2022)

Detection of Heteroplasmic Mitochondrial DNA in Single Mitochondria
por: Reiner, Joseph E., et al.
Publicado: (2010)

Heteroplasmic mitochondrial DNA variants in cardiovascular diseases
por: Calabrese, Claudia, et al.
Publicado: (2022)

Heteroplasmic mitochondrial DNA mutations in normal and tumor cells
por: He, Yiping, et al.
Publicado: (2010)

Recent Advances in Detecting Mitochondrial DNA Heteroplasmic Variations
por: Duan, Mengqin, et al.
Publicado: (2018)

Heteroplasmic mitochondrial DNA mutations in frontotemporal lobar degeneration
por: Nie, Yu, et al.
Publicado: (2022)

Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer
por: Li, Yanni, et al.
Publicado: (2023)

Heteroplasmic Variants of Mitochondrial DNA in Atherosclerotic Lesions of Human Aortic Intima
por: Sobenin, Igor A., et al.
Publicado: (2019)

A persistent mitochondrial deletion reduces fitness and sperm performance in heteroplasmic populations of C. elegans
por: Liau, Wei-Siang, et al.
Publicado: (2007)

A positive readout single transcript reporter for site-specific mRNA cleavage
por: Kandul, Nikolay, et al.
Publicado: (2017)

Heteroplasmic mitochondrial genomes of a Raillietina tapeworm in wild Pangolin
por: Tuli, Merga Daba, et al.
Publicado: (2022)

Halibut mitochondrial genomes contain extensive heteroplasmic tandem repeat arrays involved in DNA recombination
por: Mjelle, Kenneth A, et al.
Publicado: (2008)

Mitochondrial targeting of recombinant RNAs modulates the level of a heteroplasmic mutation in human mitochondrial DNA associated with Kearns Sayre Syndrome
por: Comte, Caroline, et al.
Publicado: (2013)

Detecting Rare Triple Heteroplasmic Substitutions in the Mitochondrial DNA Control Region: A Potential Concern for Forensic DNA Studies
por: Morovvati, Saeid, et al.
Publicado: (2011)

Pathogenic Heteroplasmic Somatic Mitochondrial DNA Mutation Confers Platinum-Resistance and Recurrence of High-Grade Serous Ovarian Cancer
por: Ni, Jing, et al.
Publicado: (2020)

The Detection and Partial Localisation of Heteroplasmic Mutations in the Mitochondrial Genome of Patients with Diabetic Retinopathy
por: Malik, Afshan N., et al.
Publicado: (2019)

Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro
por: Pezet, Mikael G., et al.
Publicado: (2021)

Deleterious heteroplasmic mitochondrial mutations are associated with an increased risk of overall and cancer-specific mortality
por: Hong, Yun Soo, et al.
Publicado: (2023)

Data on heteroplasmic mutations in mitochondrial genomes of loggerhead and hawksbill sea turtles: First approach
por: Delgado-Cano, David, et al.
Publicado: (2019)

Multiple Conserved Heteroplasmic Sites in tRNA Genes in the Mitochondrial Genomes of Terrestrial Isopods (Oniscidea)
por: Chandler, Christopher H., et al.
Publicado: (2015)

Structure-Related Differences between Cytochrome Oxidase I Proteins in a Stable Heteroplasmic Mitochondrial System
por: Skibinski, David O F, et al.
Publicado: (2017)

Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse
por: Filograna, R., et al.
Publicado: (2019)

Organelle bottlenecks facilitate evolvability by traversing heteroplasmic fitness valleys
por: Radzvilavicius, Arunas L., et al.
Publicado: (2022)

No evidence for learned mating discrimination in male Drosophila pseudoobscura
por: Kandul, Nikolai P, et al.
Publicado: (2006)

Mitochondrially targeted ZFNs for selective degradation of pathogenic mitochondrial genomes bearing large-scale deletions or point mutations
por: Gammage, Payam A, et al.
Publicado: (2014)

A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA
por: Iannello, Mariangela, et al.
Publicado: (2021)

Lack of Structural Variation but Extensive Length Polymorphisms and Heteroplasmic Length Variations in the Mitochondrial DNA Control Region of Highly Inbred Crested Ibis, Nipponia nippon
por: He, Xue-Lian, et al.
Publicado: (2013)

A drug-inducible sex-separation technique for insects
por: Kandul, Nikolay P., et al.
Publicado: (2020)

Plant organellar genomes utilize gene conversion to drive heteroplasmic sorting
por: Schaffner, Samantha H., et al.
Publicado: (2022)

Elimination of Mutant mtDNA by an Optimized mpTALEN Restores Differentiation Capacities of Heteroplasmic MELAS-iPSCs
por: Yahata, Naoki, et al.
Publicado: (2020)

An Inherited Heteroplasmic Mutation in Mitochondrial Gene COI in a Patient with Prostate Cancer Alters Reactive Oxygen, Reactive Nitrogen and Proliferation
por: Arnold, Rebecca S., et al.
Publicado: (2013)

Intraspecific and heteroplasmic variations, gene losses and inversions in the chloroplast genome of Astragalus membranaceus
por: Lei, Wanjun, et al.
Publicado: (2016)

Editor’s Note: A Naturally Heteroplasmic Clam Provides Clues about the Effects of Genetic Bottleneck on Paternal mtDNA
Publicado: (2021)

Selfish Little Circles: Transmission Bias and Evolution of Large Deletion-Bearing Mitochondrial DNA in Caenorhabditis briggsae Nematodes
por: Clark, Katie A., et al.
Publicado: (2012)

Ketogenic treatment reduces the percentage of a LHON heteroplasmic mutation and increases mtDNA amount of a LHON homoplasmic mutation
por: Emperador, Sonia, et al.
Publicado: (2019)

Reducing the Number of Mismatches between Hairs and Buccal References When Analysing mtDNA Heteroplasmic Variation by Massively Parallel Sequencing
por: van der Gaag, Kristiaan J., et al.
Publicado: (2020)

Mitochondrial fragmentation drives selective removal of deleterious mtDNA in the germline
por: Lieber, Toby, et al.
Publicado: (2019)

Large introns in relation to alternative splicing and gene evolution: a case study of Drosophila bruno-3
por: Kandul, Nikolai P, et al.
Publicado: (2009)

A Chinese Family With Adult-Onset Leigh-Like Syndrome Caused by the Heteroplasmic m.10191T>C Mutation in the Mitochondrial MTND3 Gene
por: Li, Tao-Ran, et al.
Publicado: (2019)

Roles of the mitochondrial replisome in mitochondrial DNA deletion formation
por: Oliveira, Marcos T., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_al5t2tjb8cppksv7l7masit0fh