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Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion
Insulin-secreting beta cells play an essential role in maintaining physiological blood glucose levels, and their dysfunction leads to the development of diabetes. To elucidate the signalling events regulating insulin secretion, we applied a recently developed phosphoproteomics workflow. We quantifie...
Autores principales: | Sacco, Francesca, Humphrey, Sean J., Cox, Jürgen, Mischnik, Marcel, Schulte, Anke, Klabunde, Thomas, Schäfer, Matthias, Mann, Matthias |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114537/ https://www.ncbi.nlm.nih.gov/pubmed/27841257 http://dx.doi.org/10.1038/ncomms13250 |
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