Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

Amyloid-β (Aβ) plaques, a hallmark of Alzheimer's disease (AD), are surrounded by regions of neuronal and glial hyperactivity. We use in vivo two-photon and wide-field imaging of the glutamate sensor iGluSnFR to determine whether pathological changes in glutamate dynamics in the immediate vicin...

Descripción completa

Detalles Bibliográficos
Autores principales: Hefendehl, J. K., LeDue, J., Ko, R. W. Y., Mahler, J., Murphy, T. H., MacVicar, B. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114608/
https://www.ncbi.nlm.nih.gov/pubmed/27834383
http://dx.doi.org/10.1038/ncomms13441

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114608/
https://www.ncbi.nlm.nih.gov/pubmed/27834383
http://dx.doi.org/10.1038/ncomms13441

Ejemplares similares