Tet1-dependent epigenetic modification of BDNF expression in dorsal horn neurons mediates neuropathic pain in rats

Ten-eleven translocation methylcytosine dioxygenase 1 (Tet1) mediates the conversion of 5-methylcytosine (5 mC) to 5-hydroxymethylcytosine (5 hmC), hence promoting DNA demethylation. Although recent studies have linked the DNA demethylation of specific genes to pain hypersensitivity, the role of spi...

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Detalles Bibliográficos
Autores principales: Hsieh, Ming-Chun, Lai, Cheng-Yuan, Ho, Yu-Cheng, Wang, Hsueh-Hsiao, Cheng, Jen-Kun, Chau, Yat-Pang, Peng, Hsien-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114645/
https://www.ncbi.nlm.nih.gov/pubmed/27857218
http://dx.doi.org/10.1038/srep37411

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114645/
https://www.ncbi.nlm.nih.gov/pubmed/27857218
http://dx.doi.org/10.1038/srep37411

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