Molecular Mechanism of Action of Antimalarial Benzoisothiazolones: Species-Selective Inhibitors of the Plasmodium spp. MEP Pathway enzyme, IspD

The methylerythritol phosphate (MEP) pathway is an essential metabolic pathway found in malaria parasites, but absent in mammals, making it a highly attractive target for the discovery of novel and selective antimalarial therapies. Using high-throughput screening, we have identified 2-phenyl benzo[d...

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Detalles Bibliográficos
Autores principales: Price, Kathryn E., Armstrong, Christopher M., Imlay, Leah S., Hodge, Dana M., Pidathala, C., Roberts, Natalie J., Park, Jooyoung, Mikati, Marwa, Sharma, Raman, Lawrenson, Alexandre S., Tolia, Niraj H., Berry, Neil G., O’Neill, Paul M., John, Audrey R. Odom
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114681/
https://www.ncbi.nlm.nih.gov/pubmed/27857147
http://dx.doi.org/10.1038/srep36777

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114681/
https://www.ncbi.nlm.nih.gov/pubmed/27857147
http://dx.doi.org/10.1038/srep36777

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