Inter-isoform Hetero-dimerization of Human UDP-Glucuronosyltransferases (UGTs) 1A1, 1A9, and 2B7 and Impacts on Glucuronidation Activity

Human UDP-glucuronosyltransferases (UGTs) play a pivotal role in phase II metabolism by catalyzing the glucuronidation of endobiotics and xenobiotics. The catalytic activities of UGTs are highly impacted by both genetic polymorphisms and oligomerization. The present study aimed to assess the inter-i...

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Detalles Bibliográficos
Autores principales: Yuan, Ling-Min, Gao, Zhang-Zhao, Sun, Hong-Ying, Qian, Sai-Nan, Xiao, Yong-Sheng, Sun, Lian-Li, Zeng, Su
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114717/
https://www.ncbi.nlm.nih.gov/pubmed/27857056
http://dx.doi.org/10.1038/srep34450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114717/
https://www.ncbi.nlm.nih.gov/pubmed/27857056
http://dx.doi.org/10.1038/srep34450

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