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Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation
BACKGROUND: Tolerance seriously impedes the application of morphine in clinical medicine. Thus, it is necessary to investigate the exact mechanisms and efficient treatment. Microglial activation and neuroinflammation in the spinal cord are thought to play pivotal roles on the genesis and maintaining...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114746/ https://www.ncbi.nlm.nih.gov/pubmed/27855689 http://dx.doi.org/10.1186/s12974-016-0754-9 |