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Metformin reduces morphine tolerance by inhibiting microglial-mediated neuroinflammation

BACKGROUND: Tolerance seriously impedes the application of morphine in clinical medicine. Thus, it is necessary to investigate the exact mechanisms and efficient treatment. Microglial activation and neuroinflammation in the spinal cord are thought to play pivotal roles on the genesis and maintaining...

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Detalles Bibliográficos
Autores principales:	Pan, Yinbing, Sun, Xiaodi, Jiang, Lai, Hu, Liang, Kong, Hong, Han, Yuan, Qian, Cheng, Song, Chao, Qian, Yanning, Liu, Wentao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2016
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114746/ https://www.ncbi.nlm.nih.gov/pubmed/27855689 http://dx.doi.org/10.1186/s12974-016-0754-9

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