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The continuum of causality in human genetic disorders
Studies of human genetic disorders have traditionally followed a reductionist paradigm. Traits are defined as Mendelian or complex based on family pedigree and population data, whereas alleles are deemed rare, common, benign, or deleterious based on their population frequencies. The availability of...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114767/ https://www.ncbi.nlm.nih.gov/pubmed/27855690 http://dx.doi.org/10.1186/s13059-016-1107-9 |