Latent mitochondrial DNA deletion mutations drive muscle fiber loss at old age

With age, somatically derived mitochondrial DNA (mtDNA) deletion mutations arise in many tissues and species. In skeletal muscle, deletion mutations clonally accumulate along the length of individual fibers. At high intrafiber abundances, these mutations disrupt individual cell respiration and are l...

Descripción completa

Detalles Bibliográficos
Autores principales: Herbst, Allen, Wanagat, Jonathan, Cheema, Nashwa, Widjaja, Kevin, McKenzie, Debbie, Aiken, Judd M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114866/
https://www.ncbi.nlm.nih.gov/pubmed/27561813
http://dx.doi.org/10.1111/acel.12520

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114866/
https://www.ncbi.nlm.nih.gov/pubmed/27561813
http://dx.doi.org/10.1111/acel.12520

Ejemplares similares