Givinostat, a type II histone deacetylase inhibitor, induces potent caspase-dependent apoptosis in human lymphoblastic leukemia

Unlike chronic myeloid leukemia, patients with acute lymphoblastic leukemia (ALL) with Philadelphia chromosome (Ph+) do not respond well to Imatinib or tyrosine kinase inhibitors (TKI). In addition, TKI might induce resistant mutations in kinase domain (KD) of ABL in patients with relapsed diseases....

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Ying, Zhao, Kevin, Yao, Chenjiao, Kahwash, Samir, Tang, Yan, Zhang, Guojiuan, Patterson, Kara, Wang, Qi-En, Zhao, Weiqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115170/
https://www.ncbi.nlm.nih.gov/pubmed/28050230
http://dx.doi.org/10.18632/genesandcancer.117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115170/
https://www.ncbi.nlm.nih.gov/pubmed/28050230
http://dx.doi.org/10.18632/genesandcancer.117

Ejemplares similares