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Givinostat, a type II histone deacetylase inhibitor, induces potent caspase-dependent apoptosis in human lymphoblastic leukemia

Unlike chronic myeloid leukemia, patients with acute lymphoblastic leukemia (ALL) with Philadelphia chromosome (Ph+) do not respond well to Imatinib or tyrosine kinase inhibitors (TKI). In addition, TKI might induce resistant mutations in kinase domain (KD) of ABL in patients with relapsed diseases....

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Detalles Bibliográficos
Autores principales:	Li, Ying, Zhao, Kevin, Yao, Chenjiao, Kahwash, Samir, Tang, Yan, Zhang, Guojiuan, Patterson, Kara, Wang, Qi-En, Zhao, Weiqiang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115170/ https://www.ncbi.nlm.nih.gov/pubmed/28050230 http://dx.doi.org/10.18632/genesandcancer.117

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