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Metabolic flexibility of mitochondrial respiratory chain disorders predicted by computer modelling

Mitochondrial respiratory chain dysfunction causes a variety of life-threatening diseases affecting about 1 in 4300 adults. These diseases are genetically heterogeneous, but have the same outcome; reduced activity of mitochondrial respiratory chain complexes causing decreased ATP production and pote...

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Detalles Bibliográficos
Autores principales: Zieliński, Łukasz P, Smith, Anthony C, Smith, Alexander G, Robinson, Alan J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115619/
https://www.ncbi.nlm.nih.gov/pubmed/27697518
http://dx.doi.org/10.1016/j.mito.2016.09.003