Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways

The recent studies have revealed that most BRAF inhibitors can paradoxically induce kinase activation by promoting dimerization and enzyme transactivation. Despite rapidly growing number of structural and functional studies about the BRAF dimer complexes, the molecular basis of paradoxical activatio...

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Detalles Bibliográficos
Autores principales: Tse, Amanda, Verkhivker, Gennady M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115767/
https://www.ncbi.nlm.nih.gov/pubmed/27861609
http://dx.doi.org/10.1371/journal.pone.0166583

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115767/
https://www.ncbi.nlm.nih.gov/pubmed/27861609
http://dx.doi.org/10.1371/journal.pone.0166583

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