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Propagated but Topologically Distributed Forebrain Neurons Expressing Alpha-Synuclein in Aged Macaques

In neurodegenerative disorders, such as Parkinson's disease (PD), alpha-synuclein (α-syn) accumulates to induce cell death and/or form a cytoplasmic inclusion called Lewy body (LB). This α-syn-related pathology is termed synucleinopathy. It remains unclear how α-syn accumulation expands during...

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Detalles Bibliográficos
Autores principales: Kimura, Katsuo, Inoue, Ken-ichi, Kuroiwa, Yoshiyuki, Tanaka, Fumiaki, Takada, Masahiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115821/
https://www.ncbi.nlm.nih.gov/pubmed/27861638
http://dx.doi.org/10.1371/journal.pone.0166861