A Solution to the Common Problem of the Synthesis and Applications of Hexachlorofluorescein Labeled Oligonucleotides

A common problem of the preparation of hexachlorofluorescein labeled oligonucleotides is the transformation of the fluorophore to an arylacridine derivative under standard ammonolysis conditions. We show here that the arylacridine byproduct with distinct optical characteristics cannot be efficiently...

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Detalles Bibliográficos
Autores principales: Chuvilin, Andrey N., Smirnov, Igor P., Mosina, Alena G., Varizhuk, Anna M., Pozmogova, Galina E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115841/
https://www.ncbi.nlm.nih.gov/pubmed/27861573
http://dx.doi.org/10.1371/journal.pone.0166911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115841/
https://www.ncbi.nlm.nih.gov/pubmed/27861573
http://dx.doi.org/10.1371/journal.pone.0166911

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