A transmission-virulence evolutionary trade-off explains attenuation of HIV-1 in Uganda

Evolutionary theory hypothesizes that intermediate virulence maximizes pathogen fitness as a result of a trade-off between virulence and transmission, but empirical evidence remains scarce. We bridge this gap using data from a large and long-standing HIV-1 prospective cohort, in Uganda. We use an ep...

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Detalles Bibliográficos
Autores principales: Blanquart, François, Grabowski, Mary Kate, Herbeck, Joshua, Nalugoda, Fred, Serwadda, David, Eller, Michael A, Robb, Merlin L, Gray, Ronald, Kigozi, Godfrey, Laeyendecker, Oliver, Lythgoe, Katrina A, Nakigozi, Gertrude, Quinn, Thomas C, Reynolds, Steven J, Wawer, Maria J, Fraser, Christophe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2016
Materias:
Epidemiology and Global Health
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115872/
https://www.ncbi.nlm.nih.gov/pubmed/27815945
http://dx.doi.org/10.7554/eLife.20492

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115872/
https://www.ncbi.nlm.nih.gov/pubmed/27815945
http://dx.doi.org/10.7554/eLife.20492

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