Decreased mTOR signalling reduces mitochondrial ROS in brain via accumulation of the telomerase protein TERT within mitochondria

Telomerase in its canonical function maintains telomeres in dividing cells. In addition, the telomerase protein TERT has non-telomeric functions such as shuttling to mitochondria resulting in a decreased oxidative stress, DNA damage and apoptosis. TERT protein persists in adult neurons and can co-lo...

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Detalles Bibliográficos
Autores principales: Miwa, Satomi, Czapiewski, Rafal, Wan, Tengfei, Bell, Amy, Hill, Kirsten N., von Zglinicki, Thomas, Saretzki, Gabriele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115906/
https://www.ncbi.nlm.nih.gov/pubmed/27777385
http://dx.doi.org/10.18632/aging.101089

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5115906/
https://www.ncbi.nlm.nih.gov/pubmed/27777385
http://dx.doi.org/10.18632/aging.101089

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