BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity

Oncogene-evoked replication stress (RS) fuels genomic instability in diverse cancer types. Here we report that BRCA1, traditionally regarded a tumour suppressor, plays an unexpected tumour-promoting role in glioblastoma (GBM), safeguarding a protective response to supraphysiological RS levels. Highe...

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Detalles Bibliográficos
Autores principales: Rasmussen, Rikke D., Gajjar, Madhavsai K., Tuckova, Lucie, Jensen, Kamilla E., Maya-Mendoza, Apolinar, Holst, Camilla B., Møllgaard, Kjeld, Rasmussen, Jane S., Brennum, Jannick, Bartek, Jiri, Syrucek, Martin, Sedlakova, Eva, Andersen, Klaus K., Frederiksen, Marie H., Hamerlik, Petra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116074/
https://www.ncbi.nlm.nih.gov/pubmed/27845331
http://dx.doi.org/10.1038/ncomms13398

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116074/
https://www.ncbi.nlm.nih.gov/pubmed/27845331
http://dx.doi.org/10.1038/ncomms13398

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