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Phenotypic correction of Fanconi anemia cells in the murine bone marrow after carrier cell mediated delivery of lentiviral vector

Fanconi anemia (FA) is an autosomal-recessive disorder associated with hematopoietic failure and it is a candidate for hematopoietic stem cell (HSC)-directed gene therapy. However, the characteristically reduced HSC numbers found in FA patients, their ineffective mobilization from the marrow, and re...

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Detalles Bibliográficos
Autores principales: Chakkaramakkil Verghese, Santhosh, Goloviznina, Natalya A., Kurre, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116221/
https://www.ncbi.nlm.nih.gov/pubmed/27865213
http://dx.doi.org/10.1186/s13287-016-0431-z