PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model

7,12-Dimethylbenz(a)anthracene (DMBA) rapidly suppresses hematopoietic progenitors, measured as colony forming units (CFU), in mouse bone marrow (BM) leading to mature cell losses as replenishment fails. These losses are mediated by Cyp1b1, independent of the AhR, despite induction of Cyp1b1. BM mes...

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Detalles Bibliográficos
Autores principales: Rondelli, Catherine M., Larsen, Michele Campaigne, N'jai, Alhaji, Czuprynski, Charles J., Jefcoate, Colin R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116507/
https://www.ncbi.nlm.nih.gov/pubmed/27891153
http://dx.doi.org/10.1155/2016/1753491

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116507/
https://www.ncbi.nlm.nih.gov/pubmed/27891153
http://dx.doi.org/10.1155/2016/1753491

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