Cargando…

PAHs Target Hematopoietic Linages in Bone Marrow through Cyp1b1 Primarily in Mesenchymal Stromal Cells but Not AhR: A Reconstituted In Vitro Model

7,12-Dimethylbenz(a)anthracene (DMBA) rapidly suppresses hematopoietic progenitors, measured as colony forming units (CFU), in mouse bone marrow (BM) leading to mature cell losses as replenishment fails. These losses are mediated by Cyp1b1, independent of the AhR, despite induction of Cyp1b1. BM mes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rondelli, Catherine M., Larsen, Michele Campaigne, N'jai, Alhaji, Czuprynski, Charles J., Jefcoate, Colin R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2016
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5116507/ https://www.ncbi.nlm.nih.gov/pubmed/27891153 http://dx.doi.org/10.1155/2016/1753491

Ejemplares similares

Cyp1b1‐mediated suppression of lymphoid progenitors in bone marrow by polycyclic aromatic hydrocarbons coordinately impacts spleen and thymus: a selective role for the Ah Receptor
por: Larsen, Michele Campaigne, et al.
Publicado: (2016)

Effect of TBT and PAHs on CYP1A, AhR and Vitellogenin Gene Expression in the Japanese Eel, Anguilla japonica
por: Choi, Min Seop, et al.
Publicado: (2012)

Serotonin Modulates AhR Activation by Interfering with CYP1A1-Mediated Clearance of AhR Ligands
por: Manzella, Christopher R., et al.
Publicado: (2020)

Cytochrome P4501B1 in bone marrow is co-expressed with key markers of mesenchymal stem cells. BMS2 cell line models PAH disruption of bone marrow niche development functions
por: Larsen, Michele Campaigne, et al.
Publicado: (2020)

Serotonin is an endogenous regulator of intestinal CYP1A1 via AhR
por: Manzella, Christopher, et al.
Publicado: (2018)

AhR activation underlies the CYP1A autoinduction by A-998679 in rats
por: Liguori, Michael J., et al.
Publicado: (2012)

The Landscape of AhR Regulators and Coregulators to Fine-Tune AhR Functions
por: Gargaro, Marco, et al.
Publicado: (2021)

Coactivator Recruitment of AhR/ARNT1
por: Endler, Alexander, et al.
Publicado: (2014)

Loss of HIF-1β in macrophages attenuates AhR/ARNT-mediated tumorigenesis in a PAH-driven tumor model
por: Henke, Nina, et al.
Publicado: (2016)

Transgenic Overexpression of Aryl Hydrocarbon Receptor Repressor (AhRR) and AhR-Mediated Induction of CYP1A1, Cytokines, and Acute Toxicity
por: Vogel, Christoph F.A., et al.
Publicado: (2016)

Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter
por: Xie, Xuan, et al.
Publicado: (2018)

AhR promotes phosphorylation of ARNT isoform 1 in human T cell malignancies as a switch for optimal AhR activity
por: Bourner, Luke A., et al.
Publicado: (2022)

Taxifolin suppresses the malignant progression of gastric cancer by regulating the AhR/CYP1A1 signaling pathway
por: Xie, Jiebin, et al.
Publicado: (2021)

Cyp1b1 directs Srebp-mediated cholesterol and retinoid synthesis in perinatal liver; Association with retinoic acid activity during fetal development
por: Maguire, Meghan, et al.
Publicado: (2020)

STARD1 Functions in Mitochondrial Cholesterol Metabolism and Nascent HDL Formation. Gene Expression and Molecular mRNA Imaging Show Novel Splicing and a 1:1 Mitochondrial Association
por: Larsen, Michele Campaigne, et al.
Publicado: (2020)

Species-Specific Differential AhR Expression Protects Human Neural Progenitor Cells against Developmental Neurotoxicity of PAHs
por: Gassmann, Kathrin, et al.
Publicado: (2010)

AhR and IDO1 in pathogenesis of Covid-19 and the “Systemic AhR Activation Syndrome:” a translational review and therapeutic perspectives
por: Turski, Waldemar A., et al.
Publicado: (2020)

Tumor-Suppressive Functions of the Aryl Hydrocarbon Receptor (AhR) and AhR as a Therapeutic Target in Cancer
por: Elson, Daniel J., et al.
Publicado: (2023)

Mitochondrial activity and oxidative stress functions are influenced by the activation of AhR-induced CYP1A1 overexpression in cardiomyocytes
por: Zhou, Bing, et al.
Publicado: (2017)

Gene expression profiling of bovine bronchial epithelial cells exposed in vitro to bovine herpesvirus 1 and Mannheimia haemolytica
por: N’jai, Alhaji U., et al.
Publicado: (2013)

ZNF165 Is Involved in the Regulation of Immune Microenvironment and Promoting the Proliferation and Migration of Hepatocellular Carcinoma by AhR/CYP1A1
por: Liu, Peng, et al.
Publicado: (2022)

NUPR1 contributes to radiation resistance by maintaining ROS homeostasis via AhR/CYP signal axis in hepatocellular carcinoma
por: Zhan, Yizhi, et al.
Publicado: (2022)

AhR signaling pathways and regulatory functions
por: Larigot, Lucie, et al.
Publicado: (2018)

Epigenetic Regulations of AhR in the Aspect of Immunomodulation
por: Wajda, Anna, et al.
Publicado: (2020)

AhR-Mediated, Non-Genomic Modulation of IDO1 Function
por: Pallotta, Maria Teresa, et al.
Publicado: (2014)

The Coevolution of IDO1 and AhR in the Emergence of Regulatory T-Cells in Mammals
por: Grohmann, Ursula, et al.
Publicado: (2015)

StemRegenin-1 Attenuates Endothelial Progenitor Cell Senescence by Regulating the AhR Pathway-Mediated CYP1A1 and ROS Generation
por: Lim, Hye Ji, et al.
Publicado: (2023)

Ethyl Caffeate Can Inhibit Aryl Hydrocarbon Receptor (AhR) Signaling and AhR-Mediated Potentiation of Mast Cell Activation
por: Nguyen, Phuc-Tan, et al.
Publicado: (2023)

Endogenous AhR agonist FICZ accumulates in rainbow trout (Oncorhynchus mykiss) alevins exposed to a mixture of two PAHs, retene and fluoranthene
por: Eriksson, Andreas N. M., et al.
Publicado: (2022)

LINAG Phase I: a technical report - version 1.3
por: Mittig, W
Publicado: (2002)

Role of AhR/ARNT system in skin homeostasis
por: Furue, Masutaka, et al.
Publicado: (2014)

Bidirectional talk between AhR and Oct4
por: Kang, Bo, et al.
Publicado: (2015)

Induction of AhR-Mediated Gene Transcription by Coffee
por: Ishikawa, Toshio, et al.
Publicado: (2014)

New Treatments in Renal Cancer: The AhR Ligands
por: Itkin, Boris, et al.
Publicado: (2020)

Herbal Plants: The Role of AhR in Mediating Immunomodulation
por: Bungsu, Izzah, et al.
Publicado: (2021)

Tryptophan Feeding of the IDO1-AhR Axis in Host–Microbial Symbiosis
por: Zelante, Teresa, et al.
Publicado: (2014)

Taxifolin Inhibits 7,12-Dimethylbenz(a)anthracene-induced Breast Carcinogenesis by Regulating AhR/CYP1A1 Signaling Pathway
por: Haque, Md. Wasimul, et al.
Publicado: (2017)

Estradiol and Progesterone Exhibit Similar Patterns of Hepatic Gene Expression Regulation in the Bovine Model
por: Piccinato, Carla A., et al.
Publicado: (2013)

Transcription Factors AhR/ARNT Regulate the Expression of CYP6CY3 and CYP6CY4 Switch Conferring Nicotine Adaptation
por: Pan, Yiou, et al.
Publicado: (2019)

AhR and HIF-1α Signaling Pathways in Benign Meningioma under Hypoxia
por: Perepechaeva, Maria L., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_33372qpnnr7fcbptjam3fb9tsn