The centrosomal deubiquitylase USP21 regulates Gli1 transcriptional activity and stability

USP21 is a centrosome-associated deubiquitylase (DUB) that has been implicated in the formation of primary cilia – crucial organelles for the regulation of the Hedgehog (Hh) signaling pathway in vertebrates. Here, we identify KCTD6 – a cullin-3 E3-ligase substrate adapter that has been previously li...

Descripción completa

Detalles Bibliográficos
Autores principales: Heride, Claire, Rigden, Daniel J., Bertsoulaki, Erithelgi, Cucchi, Danilo, De Smaele, Enrico, Clague, Michael J., Urbé, Sylvie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2016
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117204/
https://www.ncbi.nlm.nih.gov/pubmed/27621083
http://dx.doi.org/10.1242/jcs.188516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117204/
https://www.ncbi.nlm.nih.gov/pubmed/27621083
http://dx.doi.org/10.1242/jcs.188516

Ejemplares similares