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Long-Range Epistasis Mediated by Structural Change in a Model of Ligand Binding Proteins
Recent analyses of amino acid mutations in proteins reveal that mutations at many pairs of sites are epistatic—i.e., their effects on fitness are non—additive—the combined effect of two mutations being significantly larger or smaller than the sum of their effects considered independently. Interestin...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2016
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117711/ https://www.ncbi.nlm.nih.gov/pubmed/27870911 http://dx.doi.org/10.1371/journal.pone.0166739 |