Design and Characterization of Bivalent BET Inhibitors

Cellular signaling is often propagated by multivalent interactions. Multivalency creates avidity, allowing stable biophysical recognition. Multivalency is an attractive strategy for achieving potent binding to protein targets, as the affinity of bivalent ligands is often greater than the sum of mono...

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Detalles Bibliográficos
Autores principales: Tanaka, Minoru, Roberts, Justin M., Seo, Hyuk-Soo, Souza, Amanda, Paulk, Joshiawa, Scott, Thomas G., DeAngelo, Stephen L., Dhe-Paganon, Sirano, Bradner, James E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117811/
https://www.ncbi.nlm.nih.gov/pubmed/27775715
http://dx.doi.org/10.1038/nchembio.2209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117811/
https://www.ncbi.nlm.nih.gov/pubmed/27775715
http://dx.doi.org/10.1038/nchembio.2209

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