The ubiquitin ligase HUWE1 regulates hematopoietic stem cell maintenance and lymphoid commitment

Hematopoietic stem cells (HSCs) are dormant in the bone marrow and can be activated in response to diverse stresses to replenish all blood cell types. Here we identify the ubiquitin ligase Huwe1 as a crucial regulator of HSC functions via its post-translational control of N-myc. We found Huwe1 to be...

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Detalles Bibliográficos
Autores principales: King, Bryan, Boccalatte, Francesco, Moran-Crusio, Kelly, Wolf, Elmar, Wang, Jingjing, Kayembe, Clarisse, Lazaris, Charalampos, Yu, Xiaofeng, Aranda-Orgilles, Beatriz, Lasorella, Anna, Aifantis, Iannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117833/
https://www.ncbi.nlm.nih.gov/pubmed/27668798
http://dx.doi.org/10.1038/ni.3559

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117833/
https://www.ncbi.nlm.nih.gov/pubmed/27668798
http://dx.doi.org/10.1038/ni.3559

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