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The Zn-finger domain of MdmX suppresses cancer progression by promoting genome stability in p53-mutant cells
The MDMX (MDM4) oncogene is amplified or overexpressed in a significant percentage of human tumors. MDMX is thought to function as an oncoprotein by binding p53 tumor suppressor protein to inhibit p53-mediated transcription, and by complexing with MDM2 oncoprotein to promote MDM2-mediated degradatio...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5117848/ https://www.ncbi.nlm.nih.gov/pubmed/27694836 http://dx.doi.org/10.1038/oncsis.2016.62 |