An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain

The glucagon-like peptide-1 receptor is a class B G protein coupled receptor (GPCR) that plays key roles in glucose metabolism and is a major therapeutic target for diabetes. The classic two-domain model for class B GPCR activation proposes that the apo-state receptor is auto-inhibited by its extrac...

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Detalles Bibliográficos
Autores principales: Yin, Yanting, Zhou, X Edward, Hou, Li, Zhao, Li-Hua, Liu, Bo, Wang, Gaihong, Jiang, Yi, Melcher, Karsten, Xu, H Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118412/
https://www.ncbi.nlm.nih.gov/pubmed/27917297
http://dx.doi.org/10.1038/celldisc.2016.42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118412/
https://www.ncbi.nlm.nih.gov/pubmed/27917297
http://dx.doi.org/10.1038/celldisc.2016.42

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