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An intrinsic agonist mechanism for activation of glucagon-like peptide-1 receptor by its extracellular domain
The glucagon-like peptide-1 receptor is a class B G protein coupled receptor (GPCR) that plays key roles in glucose metabolism and is a major therapeutic target for diabetes. The classic two-domain model for class B GPCR activation proposes that the apo-state receptor is auto-inhibited by its extrac...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118412/ https://www.ncbi.nlm.nih.gov/pubmed/27917297 http://dx.doi.org/10.1038/celldisc.2016.42 |