A New Structure-Activity Relationship (SAR) Model for Predicting Drug-Induced Liver Injury, Based on Statistical and Expert-Based Structural Alerts

The prompt identification of chemical molecules with potential effects on liver may help in drug discovery and in raising the levels of protection for human health. Besides in vitro approaches, computational methods in toxicology are drawing attention. We built a structure-activity relationship (SAR...

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Detalles Bibliográficos
Autores principales: Pizzo, Fabiola, Lombardo, Anna, Manganaro, Alberto, Benfenati, Emilio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118449/
https://www.ncbi.nlm.nih.gov/pubmed/27920722
http://dx.doi.org/10.3389/fphar.2016.00442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118449/
https://www.ncbi.nlm.nih.gov/pubmed/27920722
http://dx.doi.org/10.3389/fphar.2016.00442

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