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Crosstalk among proteome, acetylome and succinylome in colon cancer HCT116 cell treated with sodium dichloroacetate

Protein lysine acetylation and succinylation play important regulatory roles in cells, both of which or each other has a close relationship. Dichloroacetate (DCA), a well-known pyruvate dehydrogenase kinase (PDK) inhibitor, has the potential to be used as anti-cancer drugs for several tumors includi...

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Detalles Bibliográficos
Autores principales: Zhu, Danxi, Hou, Lidan, Hu, Bin, Zhao, Hang, Sun, Jie, Wang, Jianhua, Meng, Xiangjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118697/
https://www.ncbi.nlm.nih.gov/pubmed/27874079
http://dx.doi.org/10.1038/srep37478