Identification of Polo-like kinase 1 interaction inhibitors using a novel cell-based assay

Polo-like kinase 1 (Plk1) plays several roles in cell division and it is a recognized cancer drug target. Plk1 levels are elevated in cancer and several types of cancer cells are hypersensitive to Plk1 inhibition. Small molecule inhibitors of the kinase domain (KD) of Plk1 have been developed. Their...

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Detalles Bibliográficos
Autores principales: Normandin, Karine, Lavallée, Jean-François, Futter, Marie, Beautrait, Alexandre, Duchaine, Jean, Guiral, Sébastien, Marinier, Anne, Archambault, Vincent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118709/
https://www.ncbi.nlm.nih.gov/pubmed/27874094
http://dx.doi.org/10.1038/srep37581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118709/
https://www.ncbi.nlm.nih.gov/pubmed/27874094
http://dx.doi.org/10.1038/srep37581

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