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Sex-Dependent Anti-Stress Effect of an α5 Subunit Containing GABA(A) Receptor Positive Allosteric Modulator

Rationale: Current first-line treatments for stress-related disorders such as major depressive disorder (MDD) act on monoaminergic systems and take weeks to achieve a therapeutic effect with poor response and low remission rates. Recent research has implicated the GABAergic system in the pathophysio...

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Detalles Bibliográficos
Autores principales: Piantadosi, Sean C., French, Beverly J., Poe, Michael M., Timić, Tamara, Marković, Bojan D., Pabba, Mohan, Seney, Marianne L., Oh, Hyunjung, Orser, Beverley A., Savić, Miroslav M., Cook, James M., Sibille, Etienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118774/
https://www.ncbi.nlm.nih.gov/pubmed/27920723
http://dx.doi.org/10.3389/fphar.2016.00446