Antimicrobial Peptide Potency is Facilitated by Greater Conformational Flexibility when Binding to Gram-negative Bacterial Inner Membranes

The interaction of antimicrobial peptides (AMPs) with the inner membrane of Gram-negative bacteria is a key determinant of their abilities to exert diverse bactericidal effects. Here we present a molecular level understanding of the initial target membrane interaction for two cationic α-helical AMPs...

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Detalles Bibliográficos
Autores principales: Amos, Sarah-Beth T. A., Vermeer, Louic S., Ferguson, Philip M., Kozlowska, Justyna, Davy, Matthew, Bui, Tam T., Drake, Alex F., Lorenz, Christian D., Mason, A. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118786/
https://www.ncbi.nlm.nih.gov/pubmed/27874065
http://dx.doi.org/10.1038/srep37639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118786/
https://www.ncbi.nlm.nih.gov/pubmed/27874065
http://dx.doi.org/10.1038/srep37639

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