Beyond Antibodies: Development of a Novel Protein Scaffold Based on Human Chaperonin 10

Human Chaperonin 10 (hCpn10) was utilised as a novel scaffold for presenting peptides of therapeutic and diagnostic significance. Molecular dynamic simulations and protein sizing analyses identified a peptide linker (P1) optimal for the formation of the quarternary hCpn10 heptamer structure. hCpn10...

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Detalles Bibliográficos
Autores principales: Alsultan, Abdulkarim M., Chin, David Y., Howard, Christopher B., de Bakker, Christopher J., Jones, Martina L., Mahler, Stephen M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118791/
https://www.ncbi.nlm.nih.gov/pubmed/27874025
http://dx.doi.org/10.1038/srep37348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118791/
https://www.ncbi.nlm.nih.gov/pubmed/27874025
http://dx.doi.org/10.1038/srep37348

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