Antiviral Activity of Bictegravir (GS-9883), a Novel Potent HIV-1 Integrase Strand Transfer Inhibitor with an Improved Resistance Profile

Bictegravir (BIC; GS-9883), a novel, potent, once-daily, unboosted inhibitor of HIV-1 integrase (IN), specifically targets IN strand transfer activity (50% inhibitory concentration [IC(50)] of 7.5 ± 0.3 nM) and HIV-1 integration in cells. BIC exhibits potent and selective in vitro antiretroviral act...

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Detalles Bibliográficos
Autores principales: Tsiang, Manuel, Jones, Gregg S., Goldsmith, Joshua, Mulato, Andrew, Hansen, Derek, Kan, Elaine, Tsai, Luong, Bam, Rujuta A., Stepan, George, Stray, Kirsten M., Niedziela-Majka, Anita, Yant, Stephen R., Yu, Helen, Kukolj, George, Cihlar, Tomas, Lazerwith, Scott E., White, Kirsten L., Jin, Haolun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2016
Materias:
Antiviral Agents
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118987/
https://www.ncbi.nlm.nih.gov/pubmed/27645238
http://dx.doi.org/10.1128/AAC.01474-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5118987/
https://www.ncbi.nlm.nih.gov/pubmed/27645238
http://dx.doi.org/10.1128/AAC.01474-16

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